I got some fixes for you gentlemen. The PC version isn't 100% fully optimized (mainly, in terms of controls), but despite the bitching you might see, it is fixable without mods. Here are some other common fixes that you might encounter:
Sound: Alot of people are reporting staticy, and glitchy sound. It's pretty easy to fix. Just change your sound output to ~44Khz @ 24bit. You can adjust it in the sound options in the control panel. Screenshots if you're windows stupid: http://i.imgur.com/IOicc.jpg
Quick note: For some reason, my creative sound options weren't adjusting it right. You'd think it'd override whatever is set in windows, but I had to do it through the windows option. Never knew this.
Control fixes: The sensitivity of the mouse, by default, is pretty shitty. Doing some of this will help you fix it:
-It's been recommended to turn off vsync. You can do it through the skyrim.ini in your my games folder (located in my documents). Put "iPresentInterval=0" under the [display] field (without the quotes, of course).
-Turning off mouse accelaration also helps. In the same folder, but in the skyrimprefs.ini, put "bMouseAcceleration=0" under your [controls] field.
-Manually tune your mouse sensitivity to what you like. You can do this in the skyrimprefs.ini file under the [controls] field. Adjust the "fMouseHeadingSensitivity" to what seems to work best for you (the differences won't show until you're actually in game. The main menu mouse sensitivity is the same). I believe the default is 0.0125. I adjusted mine to 0.0325. Works great on mine end like that, but it's up to you.
Other tweaks: Some of the old gamebyro ini tweaks will still work. You can find an ongoing test of them here:
On a side note: fuck Steam. There was no point in releasing a single player game with using a DRM that has a mixed history like that. If the game had multiplayer, I'd have a different take on it.