I've noticed that there have, recently, been a large increase of players complaining about spit, so I've decided to make a guide on how to counter spit easily, and also how to counter people who know how to counter it.  Note:  UB stands for unclean beast.  I will be using UB more than you see the word "global warming" in today's newspapers, so I figured I should let you know.

Firstly, we'll deal with the beginning game.  Here's how it goes down for every UB player:  If you win against the enemy demigod early, you will (teamates willing) WIN.  If you lose early, (once again, also can be teamate dependent) you will LOSE.  This is especially true 1 vs 1.

Two things will happen when you play UB.  You will either push the enemy out of the lane for a good amount of time, (after all, if it is obvious you will melt their face every time they try something they will not try at all) or outright kill them.  Of course, before we deal with this, we must deal with favor items.

What Favor Item to Pick:

Symbol of Purity:

Now, there has been a general answer to every single query of how to beat venom spit.  People tell you to go with the Symbol of Purity, but I wholeheartily disagree.  Yes, it is an instant cast, but it is on a 30 second cooldown.  Spit, along with other negative affects, has a low cooldown.  Spit itself recharges in 7 seconds.  (I can get it to 4)  If you charge in guns ablazing and think you're awesome dispelling his spit attack as you try to axe his face, keep in mind that you got rid of his spit attack, but with a 7 second cooldown, he can use it 4 more times before you can dispel it again.  Oh, but it's also 250 extra health right?  Congrats, instead of now taking 1800 damage from rank 1 spit, you have successfully debuffed that to 1550 damage instead.

Swift Anklet:

The most picked favor item, with a 15% extra speed boost.  You might be thinking to yourself, "With swift anklet, UB can never catch me!"  The only way to push UB out of a lane is to get close to him.  (More on this later)  Your only other option is to dumb him down with ranged attacks, and a good UB player will spit every time you try it, he will win the race and make you waste valuable time.  So if you need to run from UB, you are doing every possible thing wrong.  Also, you will never OUTRUN UB.  UB has a slow that is always active, is always faster, has a grab that drains health, has a skill that gives him more attack speed and move speed, might have taken swift anklet himself, etc.  If you run from UB you will most likely die, unless you're standing beside a tower, and if you're standing beside a tower than means you've already lost that lane of valuable creeps.

NOW FOR THE BEST OPTION:  Blood of the Fallen:

Now here's the perfect item against UB.  Firstly, we get +900 health.  This right here is amazing stuff.  It will give you a huge early game boost.  Level 1 UBs with spit will get 3 max spits off before having to use a mana pot or walk back to the crystal.  At rank 1 spit, he will do 1350 damage max if he just uses spit on you.  So you've negated a lot of the damage spit has done with just this 900 health.  (Note:  UB players start with low health, they will not engage you until they have spitted once or twice, this way they can easily kill you with half health and suffer fewer injuries.  If they go straight to melee you, you will win with superior health)  Also, this item gives you +5 health per second, negating even more damage and helping you heal through his spit gaps.  It is also worth noting this item will have great use against more than UB, whereas with Symbol of Purity you will mostly be slightly good against UB.  Statwise, it's an amazing item compaired to all other favor items. 

The beginning game:

Click on scores if you are in Patheon.  You do not need to actually see the enemy demigods to verify who they are, many expert players make this mistake themselves.  If you are playing unclean beast:

WHAT NOT TO DO:

Go with normal item setup, swift anklet, etc.  Go to a lane and start killing creeps.  You see UB, and he spits and runs.  UB players use a spit and run to get you down to about 1250 health, and the "average" player either keeps farming creeps, as this player has just underestimated spit, or the player will run and then get "smart" and decide to use a ranged dps power on the UB.  They get into range, and low and behold, UB spits on them again, and to their amazement he doesn't even have to be facing them.  The player runs again and either just keeps running or decide to try it one more time, and UB spits on the demigod again and then simply chase him down with superior speed and kill him, or just spit on him once more as he retreats behind towers, which will also kill him.  The demigod comes back and suffers the same fate, over and over again, the UB will dominate him.  The player rages over his fate, he bought all the right mana items and speed boots and he still cannot win.  He rage quits and makes a topic on the forums claiming UB is overpowered.  Even if this demigod farms another lane, UB has still won by getting easy levels from the time it took the other demigod to heal and travel, and will likely hunt that demigod down at level 4, as spit now does 800 damage per spit, and will easily kill him because of the insane extra damage and lack of extra health on that demigod.  A smart UB will never chase a demigod, he will spit on them every time they come into range until he is confident they can and will die.  And because the average player that falls victum to UB will do as I've outlined, he will win.

How to Win: As a general:

Pick up blood of the fallen and monks.  You can even sell the monks back after summoning them and then getting banded armor, (which I strongly recommend you get very early against UB, as you will basically have 1300 extra health now and +10 health a second, making you nigh unkillable) because monks start with 900 health, making them very hard to kill.  You will never take damage from spit with them healing you, and won't ever die early on in the game unless you do something dumb like run into towers.  You will literally own UB with this setup.  The monks will heal you every time you take damage, and your large health pool and health regain, which is especially impressive as this is only level 1, will completely dominate UB.  I remember playing as Sedna and UB thinking he could dominate me.  Like most UB players, he spit and runned on me twice; most UB players will do this to basically kill you.  When he noticed I took virtually no damage, (I didn't even have heal) he complained wildly in chat and rage quitted on me.  This is what this set up will do, trust me people. 

How to Win:  As a assasin:

Blood of the fallen, mana item and banded armor.  You will still be unkillable, but the fact that your level 1 skill will most likely be more powerful than a general's, it will make up for no monks.  With +10 health regain and the extra 1300 health UB will spit on you and run out of mana, and then just be worthless.  He will walk away dumbfounded back to the crystal having done virtually no damage to you.

How to win as UB:

The first time I saw monks on a general, my first expression was:  AGH!!!!!!!!!!!!!!!!!!!!!!!!!!!!!! NO!!! I AM WORTHLESS!!! EVEN IF I SPIT ON THOSE STUPID, FAT LOOKING MONKS THEY WILL JUST HEAL THEMSELVES AND THEY HAVE 900 HP AND ARE IMPOSSIBLE TO MELEE WITHOUT ME TAKING A LOT OF DAMAGE FROM THE OTHER DEMIGOD!!!  UB IS SO UNDERPOWERED AGAINST THIS!!!

I, like many UB players, started with the obvious swift anklet/poison dagger setup and proceeded to go lose horribly to a general with monks, or course I hadn't experienced an assasin health build yet.  However, after the game, I decided to understand how I lost.  When I understood, I was able to counter plan and use common sense.

Common Sense 1:  Do not pick a favor item until you engage the enemy.

I can't stress this enough, and it goes for any demigod.  You don't NEED that favor item right off the bat.  Wait until you engage.  If the enemy has monks, do not get your usual favor item.  If it is an assasin with a large hp pool, (about 23k health means they figured you out) do not pick your usual favor item.  If they are normal, congrats to you, go wild my friend.  A quick, off topic tip is to go with the amulet of teleportation, which I find the most useful.  When you see a lone demigod capping a flag, teleport to the flag and own him with spit + melee, it nets you tons of kills.

The best favor item to go with against a smart person is... blood of the fallen.  More on this later.

Common Sense 2:  Do not pick your first skill until you engage the enemy.

This is ALSO one every demigod should use.  You can save that skill point until you know exactly what they are doing.  If they have monks/large hp, don't go for spit.  If they are normal, go for spit.  Simple as that.

How to beat smart people:

Right off the bat buy banded armor and the scalemale armor, even though you are not sure if they are an average player.  It is a great boost and probably the best one you can get besides monks (but you aren't a general, of course) this early in the game.  The first mana helm won't actually do much this early in the game post level 5.  Go to the first creep lane.  LOOK AT THE DEMIGOD'S HEALTH.  If it is high, do not go for spit.  If he has monks as well, this further confirms your worries.  If he is normal, go nuts with your favor item and spit. 

If the demigod is smart, I recommend starting with ooze and blood of the fallen.  "But..." you might say, "I take damage using ooze!  He will kill me!"

Ooze makes enemies near UB 35 damage per second, and their attack speed is lowered 10%.  This both makes them easily killable and does AOE damage to kill those pesky monks off.  (Note:  Target monks first.  The enemy demigod will take damage from ooze anyways, but those monks need to die, pronto.  And since you are buffed you can take it.  Chances are he can't summon them again due to their relatively high mana cost at level 1)  However, you take 20 damage per second.  Figurtively, with your set up, it will be 10 damage per second.  And with 1300 extra health, at level 1, you will have 2850 health!  With the debuffs from ooze, your opponents, even with the anti UB set up, will heal -25 health per second now, and will have to run away or die due to UB's extra attack speed and the UB will have extra damage.  You have now done what spit does against normal players, forced them to run or outright killed them.  Ooze provides progressively more debuffing attack speed and does more damage to you, but just keep buying armor that adds health and you won't even notice, you'll be doing too much damage with your claws from inner beast.  Let's just say that when at level 10 you do 140 damage per second and give the enemy -40% attack speed, and probably have at least the Hauberk of Life which will make you barely notice the 50 damage it gives to you per second, you will still get a ton of demigod kills and now a ton of creep kills as well.  (You shouldn't even have to go post mortem, put that skill point into something else.  I usually put ooze first, then inner beast, 1 rank of foul grasp, then 1 rank of diseased claws, then stats.  Even with max ooze at end game you will gain more health than you lose)

And so, it is finished.  If you can't counter spit with this, you must be running into towers or doing insane 1 vs 3 fights with demigods... or something.  Seriously if you can't beat a spitting UB with this I don't know what to tell you.